Primary Submission Category: Randomized Designs and Analyses
Modern causal inference approaches to improve power for subgroup analysis in randomized clinical trials
Authors: Antonio D’Alessandro, Michele Santacatterina, Samrachana Adhikari, Jiyu Kim, Falco Bargagli-Stoffi, Donald Goff,
Presenting Author: Antonio D’Alessandro*
In randomized clinical trials (RCTs), subgroup analysis is often planned to evaluate the heterogeneity of treatment effects within pre-specified subgroups of interest. However, these analyses frequently have smaller sample sizes, reducing the power to detect heterogeneous effects. A way to increase power is borrowing external data from similar RCTs or observational studies. In this project, we target the conditional average treatment effect (CATE) in the original RCT as the estimand of interest, provide identification assumptions, and propose a doubly robust estimator that uses machine learning and nonparametric Bayesian techniques. Borrowing data, however, may present the additional challenge of practical violations of the positivity assumption—the conditional probability of receiving treatment in the external data source may be small, leading to large inverse weights and erroneous inferences—thus negating the potential power gains from borrowing external data. To overcome this challenge, we also propose a covariate balancing approach, an automated debiased machine learning (DML) estimator, and a calibrated DML estimator. We show improved power in various simulations and offer practical recommendations for the application of the proposed methods. Finally, we apply them to evaluate the effectiveness of citalopram for negative symptoms in first-episode schizophrenia patients across subgroups defined by duration of untreated psychosis, using data from two RCTs and an observatio